<p>Oral antimetabolites are the main drugs in the treatment of acute lymphoblastic leukaemia in children. However, children’s compliance with oral chemotherapy has been under question for many years. Nurses need to be aware of the possibility of non-compliance among this population and be involved in developing techniques and strategies in an attempt to minimise this problem. This article discusses how developing partnerships with families can help nurses tackle the issue of non-compliance in children.</p>