Aim To identify which educational interventions reduce burnout and promote wellbeing in nurses and care workers in secure settings. Method A systematic review of health, educational and criminal justice literature was undertaken to appraise relevant studies and identify educational interventions that were effective in reducing burnout. Findings There is some evidence that clinical supervision and psychological intervention training are successful in reducing burnout in nurses and care workers in secure settings. Conclusion Supportive relationships can help nurses to manage emotional stress, and continuing personal and professional development can reduce burnout in qualified nurses in secure settings.