There is an increasing trend towards self-collection of samples for sexually transmitted infection screening in lieu of genital examination and clinician-obtained urethral and cervical swabs. This article examines the advantages and disadvantages of this trend, and the effect on nursing practice particularly within integrated sexual health (ISH) services, which provide genito-urinary medicine (GUM) and contraceptive services. This article might also be of interest to nurses working within separate GUM and contraceptive services, especially those that are preparing to become ISH services.