The Glasgow Challenging Behaviour Rehabilitation Service (CBRS) was developed to provide primary health care to individuals who have been removed from mainstream general practice due to violence or aggression perpetrated against primary healthcare staff. This article describes the service and includes statistical information about the prevalence of violence and aggression in primary care. It outlines some of the political responses to increasing rates of violence and the difficulties that front line staff, encounter. It describes the way in which the CBRS has responded to the challenge, including the authors’ roles as clinical psychologists embedded in the service. It also offers practice points on how to prevent and manage violence and aggression.