There is a wealth of international publications regarding evidence-based practice in relation to administering safe and effective intramuscular (IM) injections. This article describes and examines the processes that North East London NHS Foundation Trust, an integrated mental health and community health provider and one of the biggest NHS trusts in the country, initiated to improve the IM injection technique of its qualified mental health nursing staff. It also aims to deliver up-to-date evidence-based practice relating to this area of clinical practice.